ABSTRACT
Background: Guillain-Barre Syndrome (GBS) is an autoimmune disease that may occur after infections.As Coronavirus Disease 2019 (COVID-19) may bring about GBS, it is important to assess the effect of the COVID-19 pandemic on this diseaseObjectives: This study aimed to compare the distribution and characteristics of GBS during and before theCOVID-19 pandemic in an academic referral hospital in the north of Iran.Materials & Methods: This retrospective study assessed GBS distribution and characteristics during theCOVID-19 pandemic period (from March 2020 to the end of February 2021) and before the pandemic(from March 2019 to the end of February 2020) on 5340 patients referred to the Neurology Ward ofPoursina Hospital of Guilan Province, in Iran. Result(s): There was no significant difference between GBS distribution during (0.03%) and before (0.04%)the COVID-19 pandemic (P=0.413). There were also no differences between the two periods regardingthe gender (P=0.659) and age (P=0.417) of the patients. The most common subtype of GBS during theCOVID-19 pandemic was Acute Motor and Sensory Axonal Neuropathy (AMSAN) (71.4%). In bothperiods, the most common type of treatment was intravenous administration of immune globulin. Therewas no significant difference between the two periods (P=0.838) regarding the patients' treatment response. Conclusion(s): The distribution of GBS, its subtypes, type of treatment, and response to treatment were notdifferent between the two study periodsCopyright © 2018 The Authors. This is an open access article under the CC-By-NC license
ABSTRACT
Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. COVID-19 has presented a significant challenge to the care providers of patients with MS. Objectives: The present study aimed to investigate the frequency of COVID-19 infection and its seropositivity in MS patients in Guilan, Iran, in 2021. Materials & Methods: In this analytical-cross-sectional study, all patients with relapsing-remitting MS registered in the Guilan MS Association with an expanded disability status scale of less than 5 who were referred for evaluation participated in the study. Information related to the clinical and serological symptoms of COVID-19 infection, changes in drug use, and the occurrence of new attacks were collected. Serological results of COVID-19 (IgG) among them were registered. Results: In total, 260 patients with MS (78.8% women, and 21.2% men) with a Mean±SD age of 38.7±9.9 years, and a Mean±SD duration of MS of 8.9±4.9 years were investigated. The most commonly used drugs were Dimethyl fumarate, Interferon, and Rituximab, respectively. Thirty-three patients (12.6%) had a clinical COVID-19 infection, of which 32 people had a mild and only one had a critical infection. Eight patients (1.3%) had positive COVID-19 IgG tests. No significant relationship was found between the COVID-19 infection with the type of medication, medication change, clinical attack of MS, and co-morbidities (P>0.05). Conclusion: A few patients had positive COVID-19 IgG tests and clinical COVID-19 infection. The vast majority had mild disease, and the clinical attack was not related to COVID-19 infection. © 2018 The Authors. This is an open access article under the CC-By-NC license.
ABSTRACT
Background: The COVID-19 pandemic has had unpleasant consequences for health care providers, including medical stagers and intern students;due to the importance of this issue, this study was conducted to evaluate anxiety, resilience and burnout. Methods: This cross-sectional analytical study was performed on stager and intern medical students of Guilan University of Medical Sciences in Rasht, Iran. Data were collected using a list containing Student Demographic Information, Maslach Burnout Inventory-Student Survey (MBISS), Academic Resilience Inventory (ARI) and Corona Disease Anxiety Scale (CDAS). Data analysis was performed using SPSS v.19 at the level of significance 0.05. Results: High levels of burnout and anxiety were calculated to be 21.1 and 7%, respectively. Burnout score was higher in people with grade point average less than 17 (p=0.014);burnout score was also higher in males (p=0.009). Other results showed that COVID-19 anxiety score was significantly higher in females (p=0.029). The results of multivariate linear regression indicated that the variables including academic resilience (β=0.330) and COVID-19 anxiety (β=0.218) significantly explain 20% of the variance of burnout in students. Also, with the introduction of demographic variables, it was increased to 31% in which the share of gender variable (β=0.283) was significant in this model. Conclusion: Academic resilience, anxiety and gender had an effective role on the rate of student burnout. Accordingly, it is suggested that health care providers and psychologists pay attention to student empowerment by providing appropriate therapeutic interventions during and after the COVID-19 epidemic. © 2022 Seventh Sense Research Group®
ABSTRACT
The aim of this study was to evaluate the burnout, anxiety, and professional self-concept of nurses according to their demographic and occupational information. 160 nurses from Razi and Poursina hospitals in Iran were selected as a sample in this cross-sectional online survey and answered the tools Demographic and Occupational Information Questionnaire (DOIQ), Maslach Burnout Inventory-Human Services Survey (MBI-HSS), Corona Disease Anxiety Scale (CDAS) and Nurse Self-Concept Questionnaire (NSCQ). Data analysis was performed in two descriptive and inferential sections using SPSS-19 statistics software. The participation rate in this study was 87.5% (n=140). The mean age was 32.56 (SD=7.26) years. The burnout rate in emotional exhaustion (EE) was 24.3%, depersonalization (DP) was 32.1%, and personal accomplishment (PA) was 60.7%, 21.4% of nurses had high anxiety, and 53.6% had low NSCQ. EE score was higher in nurses with less than ten years of experience (t=2.21) and single people (t=-3.18). DP score was higher in people under 35 years (t=3.20), with work experience of fewer than ten years (t=4.34), and single people (t=-3.07). Females in PA reported more burnout (t=-2.43). CDAS score was higher in females (t=3.20). NSCQ score was higher in married people (t=-3.07). CDAS was positively correlated with EE and DP and negatively correlated with PA. NSCQ was negatively correlated with EE and DP and positively correlated with PA. At first, a high CDAS score and then celibacy, less than ten years of work experience, and a low NSCQ score were effective in multiple linear regression analysis for MBI-HSS. Copyright © 2022 Tehran University of Medical Sciences. All rights reserved.
ABSTRACT
Background: Guillain-Barré Syndrome (GBS) is an autoimmune disease that may occur after infections.As Coronavirus Disease 2019 (COVID-19) may bring about GBS, it is important to assess the effect of the COVID-19 pandemic on this diseaseObjectives: This study aimed to compare the distribution and characteristics of GBS during and before theCOVID-19 pandemic in an academic referral hospital in the north of Iran.Materials & Methods: This retrospective study assessed GBS distribution and characteristics during theCOVID-19 pandemic period (from March 2020 to the end of February 2021) and before the pandemic(from March 2019 to the end of February 2020) on 5340 patients referred to the Neurology Ward ofPoursina Hospital of Guilan Province, in Iran.Results: There was no significant difference between GBS distribution during (0.03%) and before (0.04%)the COVID-19 pandemic (P=0.413). There were also no differences between the two periods regardingthe gender (P=0.659) and age (P=0.417) of the patients. The most common subtype of GBS during theCOVID-19 pandemic was Acute Motor and Sensory Axonal Neuropathy (AMSAN) (71.4%). In bothperiods, the most common type of treatment was intravenous administration of immune globulin. Therewas no significant difference between the two periods (P=0.838) regarding the patients’ treatment response.Conclusion: The distribution of GBS, its subtypes, type of treatment, and response to treatment were notdifferent between the two study periods © 2018 The Authors. This is an open access article under the CC-By-NC license
ABSTRACT
Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus dis-ease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction of neurological disorders and promote some neuropathies. Knowledge of the spectrum of SARS-CoV-2-associated pathophysiology and neuroinvasion pathways will lead to improved clinical outcomes and better treatment algorithms. The aim of this review is to summarize available knowledge on the identification of virology, neuroinvasion mechanisms and the pathophysiology of SARS-CoV-2 in the CNS.
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak became one of the most global health challenges in the recent century. Transverse myelitis is a rare medical condition reported in few case reports following COVID-19 infection. We present a 63 years old female with post-COVID-19 transverse myelitis. The patient had paraplegia combined with autonomic symptoms and T4 sensory level. Initial treatment started with methylprednisolone. Since the patient did not respond to the prednisolone, plasmapheresis was considered for the patient. Unfortunately, the patient could not tolerate the plasmapheresis. We considered rituximab for the next plan, but unfortunately, the patient died due to respiratory failure. To date, there is no published study to evaluate different mechanisms of post/para COVID-19 transverse myelitis. However, the post/para COVID-19 transverse myelitis mechanism seems to be heterogeneous;the activation of a silent autoimmune disease can probably justify some unusual clinical presentations of a viral illness. Further studies are needed to categorize the underlying mechanisms of post/para COVID-19 transverse myelitis and effective treatments regarding the primary pathology.